Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism

Nature Reviews Cardiology, Published online: 27 September 2026; doi:10.1038/s41569-026-01334-3Venous thromboembolism (VTE) is a major cause of morbidity and death. In this Review, Bikdeli and colleagues summarize the available evidence on the worldwide incidence and outcomes of VTE, specifically deep-vein thrombosis and pulmonary embolism. Their findings reveal a substantial and, in some regions, increasing burden of disease, sources of heterogeneity and striking regional gaps in the data.

Posted on: 26 September 2026 | 7:00 pm

Beating the odds: bringing the human heart into a dish

Nature Reviews Cardiology, Published online: 17 September 2026; doi:10.1038/s41569-026-01355-yMarcos Castro-Guarda and Jolanda van der Velden describe one of the earliest studies demonstrating the feasibility of generating human induced pluripotent stem cell-derived cardiomyocytes.

Posted on: 16 September 2026 | 7:00 pm

Benefit of aficamten in non-obstructive hypertrophic cardiomyopathy

Nature Reviews Cardiology, Published online: 16 September 2026; doi:10.1038/s41569-026-01353-0Data from the ACACIA-HCM trial show that treatment with the myosin inhibitor aficamten improves exercise capacity and patient-reported health status compared with placebo in patients with non-obstructive hypertrophic cardiomyopathy.

Posted on: 15 September 2026 | 7:00 pm

Pulmonary artery denervation shows promising results for heart failure-related pulmonary hypertension

Nature Reviews Cardiology, Published online: 15 September 2026; doi:10.1038/s41569-026-01350-3Pulmonary artery denervation lowers the risk of clinical worsening in patients with pulmonary hypertension caused by left-sided heart disease and associated with heart failure who remain symptomatic despite treatment with guideline-directed medical therapy, according to findings from the PADN-HF-PH trial.

Posted on: 14 September 2026 | 7:00 pm

High-altitude hypoxia and congenital heart defects

Nature Reviews Cardiology, Published online: 15 September 2026; doi:10.1038/s41569-026-01352-1Zila-Velasque discusses the initial studies linking high-altitude hypoxia to the risk of congenital heart defects.

Posted on: 14 September 2026 | 7:00 pm

Tricuspid valve repair reduces death and HF hospitalization

Nature Reviews Cardiology, Published online: 15 September 2026; doi:10.1038/s41569-026-01351-2In patients with symptomatic severe tricuspid regurgitation, transcatheter tricuspid repair in addition to medical therapy not only improves quality of life compared with medical therapy alone, but also significantly reduces the risk of all-cause death and hospitalization for heart failure, according to the results from the investigator-initiated TRIC-I-HF-DZHK24 trial.

Posted on: 14 September 2026 | 7:00 pm

Genetic cardiomyopathy-associated myocarditis

Nature Reviews Cardiology, Published online: 08 September 2026; doi:10.1038/s41569-026-01349-wTobias Lerchner and Stephane Heymans discuss the study that provided seminal evidence linking genetic variation to susceptibility to acute myocarditis.

Posted on: 7 September 2026 | 7:00 pm

Fishing for answers: omega-3 fatty acids and cardiovascular health

Nature Reviews Cardiology, Published online: 03 September 2026; doi:10.1038/s41569-026-01347-yLudmila Caceva discusses the 1970s studies that revealed that the plasma lipid prolife of the Inuit population of Greenland, who had a low incidence of cardiovascular disease, was characterized by low levels of cholesterol, lipoproteins and triglycerides and high levels of omega-3 fatty acids and how these findings shaped dietary guidelines worldwide.

Posted on: 2 September 2026 | 7:00 pm